tag:blogger.com,1999:blog-2899165782864226363.post2242146458276441049..comments2023-04-10T09:48:11.568-04:00Comments on The Junction Potential: The Rule Of ThreeNat Blairhttp://www.blogger.com/profile/12684196915592792806noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2899165782864226363.post-17795568559190238362008-08-12T10:43:00.000-04:002008-08-12T10:43:00.000-04:00Oh jeebus, my blood pressure just spiked again. Yo...Oh jeebus, my blood pressure just spiked again. <BR/><BR/>You're so right jp. And if you're talking about TRPV1, that's one of the mammalian TRP channels we understand <I>best</I>. When it comes to TRPCs, fuggeddabutit. The pharmacology is even worse, the knowledge of expression is bad, ideas of activation mechanisms are weak, and so far knock outs haven't been much help. Don't even get me started on the whole store-operated aspect.<BR/><BR/>*blood pressure spikes again*<BR/><BR/>There's a good post in these issues though. A blog would be a good place to start hashing through some of this. Perhaps appropriately, I've been working through some of the TRP history to do a short overview of things.Nat Blairhttps://www.blogger.com/profile/12684196915592792806noreply@blogger.comtag:blogger.com,1999:blog-2899165782864226363.post-45543308326000761702008-08-12T10:28:00.000-04:002008-08-12T10:28:00.000-04:00Exactly why I am glad to be out of the TRP channel...Exactly why I am glad to be out of the TRP channel game. Such a frustrating field to try to wrap your brain around. What particularly gets me is when these compounds are treated as having any specificity whatsoever and when only agonist activity is examined. I cannot remember the paper right now but there is one out there where the authors showed that nearly every compound examined had agonist and antagonist activity at multiple channels. <BR/><BR/>On the other hand, TRP channels are still hot... I wonder what will happen when clinical trial data start to come in with severe side effects... are the TRPV1 fever failures the tip of the iceberg or just a little blip on the radar screen?Anonymousnoreply@blogger.com